Abstract
We reported that essential fatty acid(EFA) deficiency occurred in postoperative congenital biliary atresia(CBA) children could be corrected by supplementation of EFA rich powder through enterostomy in the patients whose total bile acid levels in the excreted bile were higher than critical miceller level. This study investigated the effects of EFA rich powder supplementation with artificial bile through enterostomy on blood EFA and PGs levels in 5 patients(7mos-18mos) with poor bile excretion less than critical miceller level. Linoleic acid(LA) and PGE1 levels increased significantly (p<0.05) with daily infusion of the powder (38g LA with no AA/100g powder) for 1 month, dissolved in excreted own bile mixed with artificial bile made of 2mM/l taurocholate solution. However, arachidonic acid(AA) deficiency with derangement of PCE2 and PGF2α metabolism did not improved. These findings suggest that EFA rich powder supplementation with artificial bile is an effective treatment for LA deficiency in postoperative CBA children with poor bile excretion, but it is required to continue the regimen more than 1 month for correction of AA deficiency and derangement of PGE2 and PGF2α metabolism. And addition of AA to EFA rich powder should be considered in the further study.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shimizu, T., Oguchi, S., Ohyama, S. et al. SUPPLEMENTATION OF EFA RICH POWDER WITH ARTIFICIAL BILE IN POSTOPERATIVE CBA: EFFECTS ON BLOOD EFA AND PCs. Pediatr Res 20, 702 (1986). https://doi.org/10.1203/00006450-198607000-00103
Issue Date:
DOI: https://doi.org/10.1203/00006450-198607000-00103