Abstract
Net water absorption from 5 oral rehydration solutions (ORS) of varying composition has been studied using an in vivo steady state perfusion technique in rat jejunum Tritiated water and phenol red were used as markers, each group involved 5 to 7 animals. The reference ORS used (A) was the World Health Organisation formula containing in mmol/1 Na 90 and glucose 110. B and C were commercially available ORS containing in mmol/1 B - Na 50, glucose 91 and sucrose 94 and C - Na 35 and glucose 200. D and E were similar to A with added aminoacids. D containing glycine and E glycine and glycyglycine.
The optimal net water absorption ±1SD was 7.83 ±12.2μl/min/g using A. This was significantly (P<0.001) greater than B 20.014.91; C 39.44±9.64; D 48.43±6.06 and E 49.07±9.95μl/min/g. The absorption using D or E was greater than using C (P<0.001) or B (P<0.001). Associated studies of electrolyte absorption and changes in unidirectional fluxes will also be presented. The influences of osmolality, pH and organic solutes will be discussed, with the implications for the management of diarrhoea.
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Fl, C., Bk, S., D, B. et al. ORAL REHYDRATION SOLUTIONS - EXPERIMENTAL STUDIES OF NET WATER AND ELECTROLYTE ABSORPTION. Pediatr Res 20, 702 (1986). https://doi.org/10.1203/00006450-198607000-00102
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DOI: https://doi.org/10.1203/00006450-198607000-00102