Abstract
Oligopeptide absorption in intestine is distinct of free amino acid transport and very effectively in developing animals. In the evaluation of absorptive function after birth we studied accumulation of dipeptide into brush border membranes which were incubated at various time with labelled gly-phe, gly-pro, and gly-sar. The hydrolysis rates were determined by the analysis of free amino acids with column chromatography after incubation.
Results; Time dependent uptake is increasing up to 1 min and does
not exhibit high peak values after a few seconds. Uptake is slightly higher in newborns and closely related to rates of hydrolysis. Results indicate slow permeation of intact dipeptide through the brush border membrane of newborn and adult intestine and the importance of hydrolysis in the process of oligopeptide absorption.
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Nützenadel, W., Schwarze, E. OLIGOPETIDE UPTAKE INTO BRUSH BORDER VESICLES OF NEWBORN AND ADULT RAT INTESTINE. ITS DEPENDENCE ON HYDROLYSIS. Pediatr Res 20, 702 (1986). https://doi.org/10.1203/00006450-198607000-00101
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DOI: https://doi.org/10.1203/00006450-198607000-00101