Abstract
Isolation of campylobacter pyloridis (CP) from gastric mucosa and its association with gastritis and duodenal ulcers has been shown in adults (1). we have recently succeeded in isolating CP from gastric mucosal biopsies in children as well: biopsies are transported in a medium consisting of brain-heart infusion (Difco) + 0.25% yeast extract (Difco) + 10% horse serin, then mixed in a Sorvali mixing chamber and the suspensions obtained are inoculated on Skirrow's selective nediun (Oxoid) and on a blood plate and incubated for 5 to 7 days at 37”. Suspected colonies are stained and the oxidase and urease test confirm CP.
Over the last ten years, more than 80 children and teenagers with recurrent post-prandial epigastric pain presented uith endoscopically and radiologically recognisable nodular pseudopolypoid pattern of the antrum associated, historically, uith moderate to severe inflammatory changes. Though cimetidine usually relieved pain, it failed in healing histological lesions.
CP uas found, lately, in gastric biopsies of 5 children presenting uith chronic pseudopolypoid gastritis. It uas absent in biopsies of 14 other children without gastritis undergoing endoscopy. Following treatment with amoxycillin, CP disappeared from biopsy cultures and some histological improvement occurred.
Conclusions: 1) These preliminary results are the first report of isolation of CP in chronic gastritis in children 2) Whether CP is responsible for or only associated with the disease needs long term follow up.
(1) A.B. Price et al. Gut, 24: 1183, 1985
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Cadranel, S., Rodesch, P., Goossens, H. et al. ISOLATION OF CAMPYLOBACTER PYLORIDIS IN CHRONIC GASTRITIS IN CHILDREN. Pediatr Res 20, 700 (1986). https://doi.org/10.1203/00006450-198607000-00090
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DOI: https://doi.org/10.1203/00006450-198607000-00090