Abstract
ABSTRACT. Serum somatomedin C, thymidine uptake stimulating activity, and transferrin were measured in fetal blood collected by ultrasound-guided puncture of umbilical vessels in utero during prenatal assessment for mother-tofetus transmissible infections. Serum somatomedin C and transferrin were measured by immunoassay. Thymidine activity was measured by assay of [3H]thymidine incorporation into lectin-activated human lymphocytes. Studies were conducted in 48 healthy fetuses at gestational ages 21-28 wk. From 21-24 to 25-28 wk, serum somatomedin C significantly increased from 0.05 ± 0.06 to 0.24 ± 0.03 U/ml, while thymidine activity significantly decreased from 1.41 ± 0.15 to 0.95 ± 0.06 U/ml. Transferrin levels did not change. These data suggest that the humoral control of fetal growth at midpregnancy involves mechanisms other than direct regulation by somatomedin.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thieriot-Prevost, G., Daffos, F., Forestier, F. et al. Serum Somatomedin C, Bioassayable Growth- Promoting Activity (Thymidine Activity), and Transferrin in Human Fetuses: In Utero Study. Pediatr Res 20, 71–73 (1986). https://doi.org/10.1203/00006450-198601000-00020
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198601000-00020
This article is cited by
-
Circulating levels of growth hormone, insulin-like growth factor-I and prolactin in normal, growth retarded and anencephalic human fetuses
Journal of Endocrinological Investigation (1995)