Abstract
The purpose of the present study was to evaluate PGE2 levels in chronic enteropathy. 98 children (3 months-19 years) were studied: intreated coeliac disease (UCD) with total villous atrophy (TVA) (n=12), treated coeliac disease (TCD) with normal mucosae (n=3); untreated cow's milk protein intlerance (CMPI) with partial villous atrophy (PVA) (n=10); giardiasis (n=19); idiopathic chronic enteropathy (ICE) with PVA (n=22). 32 normal biopsies were used as controls. PGE2 concentrations (ng/g tissue) in jejunal samples (per-oral suction biopsies) were measured by radio immunological assay.
A significant difference was observed between UCD and all the other groups p<0,01 but not between the latter. PGE2 concentration was significantly different in TVA versus PVA (p<0,001) or ontrols (p<0,001) and significantly correlated to the number of IEL (p<0,001). These data showed that the increase of intestinal PGE2 seems to be related to VA and to the number of intra epithelial lymphocytes (IEL).
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Olives, J., Garcia, J., Ghisolfi, J. et al. INCREASED JEJUNAL PROSTAGLANDIN PGE2 CONCENTRATIONS IN CHILDREN WITH COELIAC DISEASE. Pediatr Res 20, 694 (1986). https://doi.org/10.1203/00006450-198607000-00055
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DOI: https://doi.org/10.1203/00006450-198607000-00055