Abstract
Glucose-stimulated Na transport is abolished in small intestinal mucosae of rotavirus-infected piglets as measured in Ussing chambers. However in human infants with rotavirus diarrhoea, oral rehydration solutions containing glucose are effective. We have studied by steady state in vitro perfusion water transport in small intestines of 10 day old mice, 3 days po-it infection with rotavirus.
Net water secretion occurred in rotavirus-infected small intestines perfused with glucose-free Ringer's solution (-5.69(1.11)μl/cm/h; mean (SEM), n=5). Controls absorbed +2.61 (0.50)μl/cm/hr.
Water secretion was reversed to net absorption (+5.43(1.11 )μl/cm/hr by perfusion with WHO oral rehydration solution.
This points to a greater functional reserve for glucose-stimulated Na and water absorption in rotavirus infected mice as compared with piglets. This is in accordance with the clinical success of WHO oral rehydration solution in humans with rotavirus diarrhoea. It is also in accord with our ultrastructural observations of virus-infected villi in which mucosal damage was less severe compared with piglets.
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Starkey, W., Collins, J., Haddon, S. et al. REVERSAL OF NET SECRETION IN SMALL INTESTINAL SEGMENTS OF ROTAVIRUS-INFECTED MICE BY WHO ORAL REHYDRATION SOLUTION. Pediatr Res 20, 691 (1986). https://doi.org/10.1203/00006450-198607000-00033
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DOI: https://doi.org/10.1203/00006450-198607000-00033