Abstract
Baseline and ACTH stimulated (4OU IV infusion for 360 min) serum concentrations of deoxycorticosterone (DOC), cortisol (F), androstenedione (Δ4-A), dehy-droepiandrosterone (DHA), DHA-sulfate (DS), and aldosterone (aldo) in prepubertal children with isolated growth hormone deficiency (N=5) and in children with two or more pituitary hormone deficiencies (def) without ACTH def (N=5) were similar to those of normal prepubertal children whose age matched to bone age of hypopituitary children. However in children with two or more pituitary hormone def including ACTH def (N=5) there was a markedly low response of DOC, F,Δ4A, DHA and DS to ACTH stimulation but normal response of aldo. Hormonal response to ACTH stimulation in hGH treated hypopituitary children did not differ from the untreated hypopituitary (Hyp) children. Thus, adrenal androgen secretory function is normal in children with multiple or single pituitary hormone def providing ACTH secretion is normal, while in ACTH deficient hypopit children, adrenal androgen secretion is very low. These data suggest that ACTH is the tropic hormone involved in the maturation of adrenal androgen secretion.
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Pang, S., Legido, A., Levine, L. et al. 480 ADRENAL CORTICAL FUNCTION IN CHILDREN WITH HYPOPITUITARISM SUGGESTS ACTH IS THE PITUITARY ADRENAL ANDROGEN STIMULATING TROPIC HORMONE. Pediatr Res 19, 190 (1985). https://doi.org/10.1203/00006450-198504000-00510
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DOI: https://doi.org/10.1203/00006450-198504000-00510