Abstract
Two week old piglets were anesthetized and ventilated; the ductus arteriosus was ligated. ECG, aortic (AO) and LV pressures (P), LV dP/dt max, and phasic pulmonary (cardiac output, CO), mesenteric (Mes) and renal (Ren) flows (F) were recorded. Sequential 10 min infusions of Ip (n=8) 0.05, 0.1, 0.2 mcg/kg/min, Dp (n=6) 2, 5, 15 or Db (n=7) 2, 5, 15 meg/kg/min were given during normoxemia (NO; PO2 103±4 mmHg) and repeated during H (PO2 39±1 mm Hg). In 8 age-matched controls saline was infused and no significant (NS) changes observed. Mean percent change ± SE (p≤0.05) to the highest doses are presented.
Conclusion: 1) Dp maintained increments in LV inotropy and CO during H, while Ip did not. Db increased CO, but increases in inotropy were attenuated during H. 2) Chronotropic effects of all three drugs were attenuated by H. 3) Peripheral vascular effects during NO were not sustained during H by any drug. 4) The data suggest that Dp is most, and Ip is least effective in eliciting beneficial cardiac responses in hypoxic newborns.
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Nudel, D., Buckley, B., Petersen, B. et al. 404 COMPARATIVE EFFECTS OF ACUTE HYPOXEMIA (H) ON CARDIOVASCULAR RESPONSES TO DOPAMINE (Dp), DOBUTAMINE (Db) AND ISOPROTERENOL (Ip) IN NEONATAL SWINE. Pediatr Res 19, 178 (1985). https://doi.org/10.1203/00006450-198504000-00434
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DOI: https://doi.org/10.1203/00006450-198504000-00434