Abstract
Septic shock constitutes a serious problem requiring urgent therapy. Naloxone (N) has a potential role in this therapy; however, in pediatric patients the reports are confined to isolated cases. Further, the efficacy of methylprednisol one (M) in shock has not been established. We studied 15 infants with septic shock; 8 randomly received N (0.01 mg/kg IV) and 7 received M (30 mg/kg IV). Heart rate, mean arterial blood pressure (flush method), capillary refill, differences in temperature and hematocrit, serum lactate and arterio-venous oxygen difference (Ca-vO2) were measured one hour before, at the time and one hour after administration of N or M. We found that mean blood pressure (BP) increased by 70% one hour after N administration as compared to a 15% increase one hour after M. In addition, there was a greater reduction in Ca-vO2 following administration of N than M (P<0.05). There was no major change in heart rate and levels of serum lactate did not decrease. Our preliminary findings suggest that N significantly increases BP in infants with septic shock. Early administration of N may be effective in the therapy of these infants.
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Torres, M., Veliz, R., Durand, M. et al. 219 COMPARATIVE EFFECTS OF NALOXONE AND METHYLPREDNISO-LONE IN INFANTS WITH SEPTIC SHOCK. Pediatr Res 19, 147 (1985). https://doi.org/10.1203/00006450-198504000-00249
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DOI: https://doi.org/10.1203/00006450-198504000-00249