Abstract
We have treated 23 children aged 6-15 years affected with agammaglo bulinemia or severe hypogammaglobulinemia with IgG serum levels lower than 100 mg% with IV gammaglobulin (Sandoglobin) at the dose of 150-300 mg/kg/3 weeks for two years. The children suffered from severe and recurrent bacterial infections, mainly of the respiratory tract, leading to chronic tissue damage. The had been previously treated with IM gammaglobulins (0,8 ml/kg/3 weeks), but their serum IgG values were never higher than 75 mg%. The results are summarized in the following Table, in which we have compared the data of the follow-up after two years of treatment with IV gammaglobulin and of the follow-up after a one-year course of IM gammaglobulins.
Minor adverse reactions (chills, fever, abdominal pain) were observed only in some children and in the first months of therapy. These data demonstrate that IV administered serum immune globulin therapy dramatically reduced infectious diseases in children with immunodeficiencies.
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Businoo, L., Cantani, A., Galli, E. et al. INTRAVENOUS GAMMAGLOBULIN THERAPY IN IMMUNODEFICIENT CHILDREN. Pediatr Res 19, 1118 (1985). https://doi.org/10.1203/00006450-198510000-00278
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DOI: https://doi.org/10.1203/00006450-198510000-00278