Abstract
Theophylline concentrations in serum and in saliva obtained without and with stimulation (dil. citric acid) of 20 patients in the age range of 5-19 years on a long term theophylline therapy were simultaneously assessed within 6 hours after drug intake; at the same time several parameters of the lung function were taken. The theophylline concentration measurements were performed gaschromatographically. The saliva concentrations obtained without stimulation very strongly correlated with the serum concentrations (r=0,98; mean deviation from the regression line 0,70/ug/ml). The saliva concentrations obtained with stimulation revealed a significantly weaker correlation with the serum concentrations (r=0,82). A dependence of the concentrations from the salivation rate (m1/2 minutes) could be identified (r=0,66) in the saliva obtained with as well as in that obtained without stimulation; this dependence exists both intra- and interindividually. Reliability and evidence of the saliva concentrations obtained without stimulation can be further increased by measurement of the secreted saliva volume per period of time.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leupold, W., Feller, K., Paditz, E. et al. THEOPHYLLINE CONCENTRATION MEASUREMENTS IN SERUM OR SALIVA FOR THERAPY MONITORING IN BRONCHIAL ASTHMA. Pediatr Res 19, 1097 (1985). https://doi.org/10.1203/00006450-198510000-00170
Issue Date:
DOI: https://doi.org/10.1203/00006450-198510000-00170