Abstract
Acute attack of gout triggered by allopurinol has been studied by a retrospective analysis of 134 patients with gout treated with this drug.
The results suggest that:
a) mobilization of tophaceous deposits in the joints play an important part in the pathogenesis of the acute attack of gout triggered by allopurinol.
b) acute gouty attacks after the initiation of allopurinol therapy are more frequent and occur earlier in patients not receiving than in those receiving prophylactic colchicine or indomethacin.
The acute attack of gout triggered by allopurinol is proposed as an "ex ingravescentibus" diagnostic criteria when the patient is seen in an intercritical period.
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Sorgi, M., Giacomello, A. & Zoppini, A. ACUTE ATTACK OF GOUT TRIGGERED BY ALLOPURINOL: 202. Pediatr Res 19, 777 (1985). https://doi.org/10.1203/00006450-198507000-00222
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DOI: https://doi.org/10.1203/00006450-198507000-00222