Abstract
Quantitative assessment of hemodynamics in neonates with complete transposition (TGA) was performed using two-dimensional (2D) directed pulsed Doppler echocardiography. Both the aortic valve (RV) and pulmonary valve (LV) flow velocities were obtained in 5 neonates before and during a 1 hour infusion of prostaglandin E1 (PGE) at 0.1 mcg/kg/min following balloon atrial septostomy. Ductus arteriosus (DA) size by 2D imaging increased in all and pulmonary to aortic shunting was excluded by Doppler sampling in DA. Stroke volume changes were estimated by the product of the Doppler time-velocity integral (TVI) and heart rate (cm/min). Doppler systolic time intervals (PEP/ET) were calculated.
LV stroke volume decreased while RV stroke volume increased. The ratio of LV to RV stroke volume consistently decreased. An increase in LV and decrease in RV systolic time intervals did not reach a significant level.
Conclusions: PGE in neonates with TGA results in decreased LV stroke volume. Enhanced intraatrial mixing in TGA with PGE may be mediated, in part, by decreased LV filling.
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Huhta, J., Abdallah, S., Nihill, M. et al. 106 THE HEMODYNAMIC EFFECTS OF PROSTAGLANDIN E1 IN COMPLETE TRANSPOSITION OF THE GREAT ARTERIES. Pediatr Res 19, 128 (1985). https://doi.org/10.1203/00006450-198504000-00136
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DOI: https://doi.org/10.1203/00006450-198504000-00136