Abstract
Plasma Tg measurement was performed in a large group (n=106) of patients with congenital hypothyroidism (CH) in order to better define its role in the diagnosis and the evaluation of treatment. Patients were classified in 3 groups according to thyroid scan (I123). Plasma T4, TSH and Tg were measured prior to therapy. In addition a longitudinal study of plasma Tg was undertaken in a subgroup of 10 patients with measurable Tg treated with LT4. Results were as follow
Although Tg was undetectable in athyreosis and measurable when some thyroid was present, some discrepancies were observed. In athyreosis 5 patients had measurable Tg and T4 and have probably small thyroid tissue not seen by scintiscan. Tg was not measurable in 1 ectopic case and in 3 patients with goiter. During treatment Tg followed closely TSH with a rapid and parallel decrease of both parameters during the early weeks of therapy. In undertreated patients with elevated TSH, measurement of Tg demonstrate secretion by remnant thyroid tissue even after 12 months of therapy.
In conclusion. Tg is helpfull in the classification of patients with CH. It offers a tool for studying secretion of eutopic or ectopic thyroid glands in treated patients.
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Tar, A., Léger, J., Schlumberger, M. et al. 72 VALUE OF PLASMA THYROGLOBULIN (Tg) MEASUREMENT IN THE DIAGNOSIS AND TREATMENT OF CONGENITAL HYPOTHYROIDISM. Pediatr Res 19, 615 (1985). https://doi.org/10.1203/00006450-198506000-00092
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DOI: https://doi.org/10.1203/00006450-198506000-00092