Abstract
ABSTRACT: The tyrosine content of parenteral solutions is limited by poor tyrosine solubility. N-acetyl-L-tyrosine has excellent solubility and is a potential source of intravenous tyrosine. Infusion of N-acetyl-U-14C-L-tyrosine as part of a total parenteral nutrition regimen in the rat at a level of 0.5 mmol/kg/day resulted in rapid labeling of tissue tyrosine pools, production of 14CO2, incorporation of Relabeled tyrosine into protein, and modest urinary losses (8.3%). Plasma tyrosine levels, however, remained at fasting values (73.8 ± 5.40 μ). Infusion of N-acetyl-L-tyrosine at 2 mmol/kg/day increased plasma tyrosine above fasting levels (141 ± 16.1 μ), resulted in a rapid labeling of tissue tyrosine pools, production of 14CO2, and incorporation of 14C-labeled tyrosine into protein. However, urinary losses were higher (16.8%). Rapid utilization of N-acetyl-L-tyrosine was noted at both infusion levels. Plasma-and tissue-free tyrosine pools were rapidly labeled, as was tissue protein. Radioactivity incorporated in tissue protein was shown to be tyrosine after acid hydrolysis.
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Im Haesook, A., Meyer Paul, D. & Stegink, L. N-Acetyl-L-Tyrosine as a Tyrosine Source during Total Parenteral Nutrition in Adult Rats. Pediatr Res 19, 514–518 (1985). https://doi.org/10.1203/00006450-198506000-00002
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DOI: https://doi.org/10.1203/00006450-198506000-00002
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