Abstract
To examine ventricular wall motion in sickle cell anemia (SS), two groups of SS patients (pts) underwent digitized echocardiographic analysis. Group I consisted of 30 SS infants (mean age 0.8 yrs). Group II consisted of 70 SS pts (mean age 13.8 yrs). When these groups were compared to nonanemic controls (C) of similar age, no differences were found in shortening fraction or systolic time intervals. Computer derived information included: R-R interval, maximum (Max) and minimum (Min) LV size, Max and Min septal and freewall thickness, Max rate of septal and freewall thickening and thinning. Timing of each event was normalized as a percentage of the total R-R interval. Mean value ± standard deviation and a p value for various groups are shown below:
Adolescents with SS have abnormalities of LV dimension and wall motion which are not present in infancy. Systolic delay in achieving Min LV size may be secondary to increased stroke volume. The etiology of diastolic delay septal thinning and max cavity filling is unknown.
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Arensman, F., Covitz, W., Reyes, L. et al. 76 DIGITIZED ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT VENTRICULAR WALL MOTION IN INFANTS AND ADOLESCENTS WITH SICKLE CELL ANEMIA. Pediatr Res 19, 123 (1985). https://doi.org/10.1203/00006450-198504000-00106
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DOI: https://doi.org/10.1203/00006450-198504000-00106