Abstract
Asphyxiated term infants (A) are at risk for early-onset seizures, persistent encephalopathy, abnormal EEG's and long-term sequelae. CK-BB is elevated in preterm infants with IVH and term infants with post-asphyxial neurologic injury. We correlated CK-BB with other laboratory and clinical assessments of asphyxia in the neonatal period and with outcome at 3-6 months. Criteria for asphyxia was one or more of: Apgar (5 min) ≤ 5; need for resuscitation beyond 5 min; abnormal neurologic exam by 24 h of age with a history suggestive of perinatal asphyxia. Serum total CK and BB fraction were measured from umbilical cord blood and samples were drawn at 6-12 h and 24-36 h in 8 normal and 13 A infants. Sarnat encephalopathy staging was done daily and EEG's were obtained on days 1 and 7 for A infants. CK and BB values were not affected by route of delivery or duration of labor. Differences were seen in CK-BB measurements at 6-12 h for:
The CK-BB peak at 6-12 h rather than in cord blood suggests that the asphyxial insult was more closely related to intrapartum period than chronic intrauterine events. The best predictors of poor prognosis are a low Apgar at 5 min and neonatal seizures. CK-BB is a useful biochemical marker of significant asphyxia.
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Viseardi, R., Donn, S., Giaeherio, D. et al. 1713 SERUM CREATINE KINASE BRAIN SPECIFIC ISOENZYME (CK-BB) IN TERM ASPHYXIATED INFANTS. Pediatr Res 19, 396 (1985). https://doi.org/10.1203/00006450-198504000-01731
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DOI: https://doi.org/10.1203/00006450-198504000-01731