Abstract
Spinal fluid samples were obtained from 18 asphyxiated term (GA 40 ± 2 wks, BW 3064 ± 583 gms) neonates to determine whether CSF LDH and CPK are useful predictors of neurologic disability following perinatal asphyxia. These values were compared with CSF enzymes from 7 term (GA 40 ± 1 wk, BW 3521 ± 510 gms) nonasphyxiated infants. Asphyxia was present if the 5 min. Apgar score was < 4 or pH < 7.0 or failure to breathe by 10 min. or hypotonia persisting for 2 hrs. Spinal fluid samples were obtained from the asphyxiated infants at 11.8 ± 5.3 hrs. and from control infants at 32.4 ± 29 hrs. Neurodevelopmental follow-up ranges from 3-15 months in the 15 surviving infants. Abnormal outcome includes death (3), some form of cerebral palsy (8), abnormal Gesell screening (7) or abnormal brain stem auditory responses (4). 8 infants are presently normal.
Infants who died or survived with neurologic handicap have significantly higher CSF LDH levels than either normal survivors or control infants (p < .025). Similarly infants who died or survived with neurologic handicap have higher CSF CPK levels than normal survivors or controls (p < .01).
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Hall, F., Dally, D., Gay Kurth, C. et al. 1675 SPINAL FLUID ENZYMES AS PREDICTORS OF NEUROLOGIC OF NEUROLOGIC DISABILITY FOLLOWING PERINATAL ASPHYXIA. Pediatr Res 19, 390 (1985). https://doi.org/10.1203/00006450-198504000-01699
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DOI: https://doi.org/10.1203/00006450-198504000-01699