Abstract
Preterm baboon (B) and lambs (L) have been used as models for different surfactant studies. Varying responses have been recorded. We studied and compared the responses of these models to S-TA therapy. Animals delivered prematurely (B:76% and L:83% term) by C-section were used. All had HMD. S-TA 100 mg/kg was instilled into trachea at 2 hrs. of age. Controls received no S-TA. Sequential a/APO2 data are shown. Treated B had sustained improvement in a/APO2 up to 16 hrs. and mean airway pressure dropped from 14.5±1.1 to 10.2±0.5 cmH2O p<.001. In lambs improvement in a/APO2 was significant but transient lasting only 2-3 hrs, with deterioration by 4-5 hrs. Pressure vol. curves at autopsy showed significantly larger hysteresis in treated baboons than lambs. Two other treated baboons could be maintained alive for 36 hrs. We conclude: 1) Differences in response to S-TA therapy may be species related, 2) Baboon HMD model may be better for studies of long term effects of surfactant therapy than the lambs.
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Vidyasagar, D., Maeta, H., Matsuda, H. et al. 1552 COMPARISON OF TWO ANIMAL MODELS IN ARTIFICIAL SURFACTANT THERAPY FOR HYALINE MEMBRANE DISEASE (HMD). Pediatr Res 19, 369 (1985). https://doi.org/10.1203/00006450-198504000-01576
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DOI: https://doi.org/10.1203/00006450-198504000-01576