Abstract
The homeothermic response to ECS includes increased O2 consumption (VO2) with heat production. Anemia may blunt this response by reducing O2 transport; limiting VO2. We tested this hypothesis in four, awake 3-day old piglets during CONTROL(HCT=26.4±0.9%) and ANEMIC(HCT=14.8±0.1%) periods. Measurements of core(Tc) and ambient(Tamb) temperatures, arterial-mixed venous O2 contents, and cardiac output(CO, microsphere method) were made in a warm environment(W) and after 60 min. of ECS. Following recovery from ECS, an isovolemic plasma exchange transfusion was done to lower the HCT. W and ECS measurements were then repeated as described. The A-VΔO2, VO2 and O2 extraction (O2Ex) were calculated from measured values. Results are below (M±SEM):
Although O2 Ex increased during ECS with anemia, VO2 and, presumably, heat production were limited with resultant hypothermia. These preliminary data suggest that anemia blunts the homeothermic response to ECS in newborn piglets.
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Mayfield, S., Shaul, P., Oh, W. et al. 1454 ANEMIA BLUNTS THE NEONATAL HOMEOTHERMIC RESPONSE TO ENVIRONMENTAL COLD STRESS(ECS). Pediatr Res 19, 353 (1985). https://doi.org/10.1203/00006450-198504000-01478
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DOI: https://doi.org/10.1203/00006450-198504000-01478