Abstract
Radionuclide scans (RS) and plasma renin activities (PRA) were analyzed in 11 infants with symptomatic hypertension (SNH) diagnosed in the intensive care nursery over a period of 4 years. All infants at the time of diagnosis had abnormal unilateral renal scans (decreased perfusion and/or decreased glomerular filtration and high PRA (27-815 ng/ml/hr) except for one with normal PRA. Follow-up renal scans performed during the next 2-4 week period showed improvement in 8 out of the 11 infants. Subsequent renal scans showed no further improvement. The normalization of PRA occured over a period of 4-12 months. Antihypertensive therapy could only be discontinued when PRA returned to normal (<10 ng/ml/hour). Of the three infants who had no improvement in renal scan and did not respond to medical management, 2 required surgical nephrectomy. One underwent autonephrectomy as evidenced by absent perfusion of the involved kidney, normalization of initial high PRA and resolution of hypertension.
Hypertensive infants with early improvement of impaired renal scans are amenable to medical therapy with resolution of hypertension.
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Katikaneni, L., Purohit, D., Gordon, L. et al. 1424 RADIONUCLIDE SCANS (RS) AND PLASMA RENIN ACTIVITY IN HYPERTENSIVE NEONATES WHO RECOVER. Pediatr Res 19, 348 (1985). https://doi.org/10.1203/00006450-198504000-01448
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DOI: https://doi.org/10.1203/00006450-198504000-01448