Abstract
Venous concentrations of glucose and the carbohydrate regulatory hormones were measured at birth, 1, 4, and 12 hrs of life in 9 vaglnally delivered control babies and in 17 IDM (12 delivered by caesarian section [C/S]). Pre and perinatal maternal diabetic control was generally good. 14 IDM received standard glucose infusions after 1 hr. Biochemical data (median values; significance †):
Glucose levels at 4 and 12 hrs were higher in the IDM because of glucose infusions. Free insulin levels in the IDM were higher at all intervals. In the IDM delivered by C/S, cortisol at birth (8.5) was lower than in either IDM delivered vaglnally (20) or controls (20). Growth hormone (GH) was higher in the IDM at 1, 4 and 12 hours; the higher values at 4 and 12 hrs might be due to glucose infusion. Norepinephrine (NE) was elevated only at 1 hour in the IDM. Cortisol, epinephrlne (Epi) and glucagon values in the 2 groups were similar at all intervals.
Conclusion: Our IDM population had no deficits in their counter-regulatory hormone responses during early postnatal life. They did however have significant hyperinsulinemia.
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Gong, A., MacGillivray, M., Egan, E. et al. 1393 COMPARISON OF POSTNATAL HORMONAL CONTROL OF GLUCOSE IN OFFSPRMGS OF DIABETIC MOTHERS (IDM) AND IN HEALTHY INFANTS. Pediatr Res 19, 343 (1985). https://doi.org/10.1203/00006450-198504000-01417
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DOI: https://doi.org/10.1203/00006450-198504000-01417