Abstract
To elucidate the relationship between ductal patency (PDA), plasma prostaglandins (PG) and indanethacin (IN), 55 infants <1750 gms at birth were monitored prospectively for a hemodynamically significant PDA by exam, CXR, echo/doppler and ventilator dependence. Six received IN 0.2 mg/kg/dose for 3 doses at 12 hr. intervals. Plasma for IN, thromboxane B2(T) and 6-keto-PGF1α (6K), the stable metabolite of prostacyclin, was obtained prior to and 2, 6, 12, 18, 24, 36 hr after starting TN. Control and 12 hr interval mean results were:
The PDA closed in all infants within 24 hr. The data indicate that PDA closure correlated with rising IN concentration and decreased T synthesis while 6K did not change. This differential inhibition of PG suggests that IN preferentially accesses cycleoxygenase at different anatomic sites and that circulating T may predict efficacy of PDA closure by IN.
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Fulton, D., Berninger, R., Chung, K. et al. 1386 PLASMA PROSTAGLANDIN RESPONSE TO INDOMETHACIN THERAPY FOR PATENT DUCTUS ARTERIOSUS IN PREMATURE INFANTS. Pediatr Res 19, 341 (1985). https://doi.org/10.1203/00006450-198504000-01410
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DOI: https://doi.org/10.1203/00006450-198504000-01410