Abstract
In an effort to identify risk factors associated with the development of bronchopulmonary dysplasia (BPD) we retrospectively reviewed over a 5 year period the neonatal course of all 188 infants of <1500 g who required mechanical ventilation for >24 hours and survived at least 14 days. Infants with BPD had lower birth weights (p <.001), shorter gestations (p <.001), more frequent patent ductus arteriosus (p=.009), more often required muscle relaxation (p <.001), had interstitial air on x-ray within 7 days of birth (p=.007). A discriminative analysis utilizing these variables plus sum of the daily mean airway pressure and sum of daily mean A-aDO2 for the 2nd week of life was compared to the clinical criteria of the need for mechanical ventilation and an FiO2 >.3 at 14 days of age for the prediction of BPD. Both functions were then tested on a subsequent prospective cohort of 35 infants.
The clinical criteria correctly predicted BPD in 92% <1000 gm, 58.3% between 1000-1250 gm and 85% >1250 gm. With a specificity and sensitivity similar to the discriminant function the use of such criteria may be helpful in identifying infants who may benefit from therapeutic trials to prevent or ameliorate this disorder.
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Finer, N., Peters, K., Barrington, K. et al. 1384 RISK FACTORS FOR BRONCHOPULMONARY DYSPLASIA. Pediatr Res 19, 341 (1985). https://doi.org/10.1203/00006450-198504000-01408
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DOI: https://doi.org/10.1203/00006450-198504000-01408