Abstract
Gluconeogenesis is a major component of glucose production. The contribution of specific gluconeogenic precursors has not been studied in the newborn relative to the adult. Glucose production and lactate production have been evaluated by prime constant infusion of 45 ug·kg−1 min−1 D-[6, 6- 2D]glucose and 20 ug·kg−1 min−1 [3- 13C]lactate in 3 AGA premature(PT) [BW 2088±174 gm (M±SEM) & GA 34.3±0.9 wks] & 4 AGA term infants(T) [BW 3316±175 gms & GA 41±0.4 wks] at 31±7 hrs after birth & compared to studies in 4 adults(A). Ra(production) was measured during infusion of 0.9% NaCL at 0.06 ml · kg−1 min−1 and analyzed by Gas Chromatograph Mass Spectometry(GCMS). Turnover period results are shown:
Ra(Glucose) & Ra(Lactate) were ↑ in both PT & T relative to A, but not between PT & T. There was an ↑ ratio of Ra(Lactate) to Ra (Glucose) in both PT & T relative to A but not between PT & T. This is consistent with the relationship of Ra(Glucose) measured by the non-recycling tracer D-[6,6- 2D]glucose in these studies compared to Ra(Glucose) measured with the recycling tracer D-[U- 13C]glucose in prior studies. Availability of lactate due to recycling may be a mechanism for sparing of gluconeogenic amino acid precursors in the anabolic newborn.
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Cowett, R., Wolfe, M. & Wolfe, R. 1205 LACTATE TURNOVER IS INCREASED IN THE NEONATE RELATIVE THE ADULT. Pediatr Res 19, 311 (1985). https://doi.org/10.1203/00006450-198504000-01235
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DOI: https://doi.org/10.1203/00006450-198504000-01235