Abstract
Hemophilus influenzae vaccine containing polyribose ribitol phosphate (PRP) or PRP covalently linked to diphtheria toxoid (PRP-D) may be licensed for 18 month olds. Since the vaccine will be given at the same time as a DPT booster, reactions and antibody response to PRP-D given simultaneously with DPT were compared to PRP. 94 previously healthy infants 17-20 mo old were given PRP or PRP-D in one thigh and DPT in the other. Reactions were monitored for 48 hrs. Pre- and 1 month post-vaccine sera were analyzed for anti-PRP antibody by radioimmunoassay.
Systemic reactions were similar in the two vaccine groups and resembled those expected with the DPT shot alone. 26 (58%) of 45 PRP recipients and 22 (45%) of 49 PRP-D recipients had a rectal temperature >38°C. Only 6 (13%) and 7 (14%), respectively, of the PRP and PRP-D recipients had any local reaction to the Hemophilus vaccine.
PRP-D was more antigenic than PRP in this age group. Geometric mean levels of antibody to PRP in pre- and post-immunization sera were 0.05 and 0.32 ug/ml, respectively, in 25 PRP recipients, and 0.04 and 1.9 ug/ml, respectively, in 32 PRP-D recipients. 16 (64%) of 25 PRP recipients and 28 (88%) of 32 PRP-D recipients attained a post-vaccine antibody level of ≥0.1 ug/ml (p=0.04). 10/25 (40%) PRP recipients and 21/32 (66%) PRP-D recipients achieved an antibody level of ≥1.0 ug/ml (p=0.05). In 18 mo old infants PRP-D produced a greater antibody response to capsular polysaccharide than PRP with no increase in reactions.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hendley, J., Wenzel, J., Ashe, K. et al. 1111 SAFETY AND ANTIGENICITY OF PRP-D VACCINE ADMINISTERED SIMULTANEOUSLY WITH DPT BOOSTER TO 18 MONTH OLD INFANTS. Pediatr Res 19, 296 (1985). https://doi.org/10.1203/00006450-198504000-01141
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01141