Abstract
ABSTRACT: We characterized some of the consequences of intrauterine growth retardation in rat pups growth retarded [small for gestational age (SGA)] due to bilateral maternal uterine artery ligation. Pups of sham and nonoperated (normal) mothers served as controls. SGA pups had significantly reduced body and carcass mass throughout the study while body mass did not differ between sham and normal pups after 4 days. Brain mass was similar in the three groups at any age, while at 21 days and later, SGA liver weight as % body mass exceeded that of sham or normals. At 21 days, a 48-h fast reduced plasma glucose significantly in SGA compared to sham and normal pups; SGA plasma insulin was decreased and glucagon increased. Hepatic phosphoenolpyruvate carboxykinase activity and glycogen content were similar among groups. SGA pups did have significantly reduced plasma alanine and elevated betahydroxybutyrate levels. No differences in the responses to fasting occurred at 28 or 35 days. These data indicate that intrauterine growth retardation has profound effects on postnatal growth and metabolism.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogata, E., Bussey, M., Labarbera, A. et al. Altered Growth, Hypoglycemia, Hypoalaninemia, and Ketonemia in the Young Rat: Postnatal Consequences of Intrauterine Growth Retardation. Pediatr Res 19, 32–37 (1985). https://doi.org/10.1203/00006450-198501000-00010
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198501000-00010
This article is cited by
-
Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat
Reproductive Sciences (2021)
-
Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain
Neurochemical Research (2017)
-
Acute hypoglycemia results in reduced cortical neuronal injury in the developing IUGR rat
Pediatric Research (2015)
-
Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats
Pediatric Research (2014)
-
In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice
Particle and Fibre Toxicology (2013)