Abstract
The negative potential difference (PD) between rectal mucosa and subcutaneous (SC) space is mainly due to transmucosal sodium transport from the lumen. In order to examine the electrolyte transport defect in Cystic Fibrosis (CF) we measured change in rectal PD in response to normal saline, 10-4M amiloride, 10-4M furosemide and 0.102 M Na2SO4 applied topically. Seven CF Patients and seven Controls were in Na balance on diets containing 120 mleq Na per day. We perfused the rectum through a double lumen, double balloon catheter.
Mean Negative PD between Rectal Mucosa and SC Space
During amiloride perfusion CF patients had a significantly smaller negative rectal-SC PD than normal controls. Thus, amiloride blocked rectal Na transport more completely in CF than in normals. Rectal PDs during perfusion with normal saline and with furosemide and Na2SO4, both CF blockers, were similar for CF and normals. These data are compatible with defective facilitation of sodium transport in CF or with the presence in the normal of a non-amiloride sensative Na+ transport mechanism which is absent in CF.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Westphal, M., Trojanowski, S., Blackburn, J. et al. ELECTROPHYSIOLOGIC MEASUREMENTS OF RECTAI. MUCOSA IN CYSTIC FIBROSIS - ABNORMAL RESPONSE TO AMILORIDE. Pediatr Res 18 (Suppl 4), 217 (1984). https://doi.org/10.1203/00006450-198404001-00745
Issue Date:
DOI: https://doi.org/10.1203/00006450-198404001-00745