Abstract
We studied the effects of hypoxemia on gastric motility & GI blood flow in nine 2-4 day old piglets by determining gastric emptying (phenol red dye dilution), GI blood flow (QGI, radio-labelled microspheres), O2 delivery (DO2 GI), O2 extraction (O2 ExGI), & O2 consumption (VO2GI). Animals were mechanically ventilated (NO2 anesthesia), & studied during control (PaO2 91±8 torr), 35 minutes of hypoxemia (29±1 torr), and recovery periods (90±5 torr) (mean±SEM). Following a D10 W test meal (22ml/kg), gastric residual volumes were determined at 10-min. intervals over 30-min. study periods. The hypoxemic emptying pattern showed significantly greater gastric residuals (p<0.05) at 20 min. compared to 10 min.; however, residual volumes were not significantly different among groups at 10,20, & 30 min. Thirty minutes following the test meal, the QGI and O2 transport showed:
DO2GI fell because of decreased QGI & hypoxemia. The increased O2 ExGI did not compensate for the decreased DO2GI; therefore, VO2GI fell. We speculate that the significantly altered gastric emptying pattern and decreased QGI and VO2GI produced by hypoxemia may account for feeding intolerances seen in hypoxemic newborns.
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Szabo, J., Stonestreet, B. & Oh, W. GASTRIC MOTILITY AND GI BLOOD FLOW: EFFECTS OF HYPOXEMIA IN THE NEWBORN PIGLET. Pediatr Res 18 (Suppl 4), 214 (1984). https://doi.org/10.1203/00006450-198404001-00727
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DOI: https://doi.org/10.1203/00006450-198404001-00727