Abstract
12 AGA 28-32 week gestation infants were studied during the first 2-3 mos. of life to determine the effect of feeding premature human milk (HM), fortified premature human milk (FHM) and Similac Special Care (SSC) on growth and bone mineralization. Alkaline phosphatase (AP), tubular reabsorption of phosphate (TRP), urinary calcium excretion (uCa), serum phosphorus (P), and type I procollagen (PC) were measured. Mean results:
Poor wt gain in the HM gp was associated with a significantly lower PC. The FHM gp grew as well and had similar PC levels as the SSC gp but like the HM gp exhibited biochemical evidence of phosphorus deficiency and inadequate bone mineralization: decreased P and increased AP, TRP and uCa. The data suggest that current special formulae designed for VLBW infants promote better growth and mineralization than HM or FHM and PC may prove a useful marker of optimal growth response.
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Rowe, J., Carey, D., Goetz, C. et al. PROCOLLAGEN–BIOCHEMICAL MARKER OF GROWTH IN ENTERALLY FED VLBW INFANTS. Pediatr Res 18 (Suppl 4), 210 (1984). https://doi.org/10.1203/00006450-198404001-00703
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DOI: https://doi.org/10.1203/00006450-198404001-00703