Abstract
PGD2 infusions decrease mean pulmonary arterial pressure (Ppa) and resistence (PVR) in both fetal and hypoxic, neonatal lambs, yet cause direct pulmonary constriction in hypoxic juveniles. We gave bolus PGD2 to 19 acutely-operated lambs, 4-24 days old(d). Normoxic lambs were given 1 and 10 μg/kg with recovery time between doses. The lambs were then ventilated with 13% O2 and given the same doses of PGD2. We compared % Δ of Ppa, mean systemic arterial pressure (Pas), and PVR in lambs <7d and ≥14d.
In normoxic lambs, 1 μg/kg had no effect on Ppa and PVR at <7d but caused significant increases in ≥14d animals. Ten μg/kg raised Ppa and PVR in both younger and older normoxic lambs. In hypoxic animals, both doses lowered Ppa and PVR in the <7d group, while in the ≥14d lambs there was little or no pulmonary effect. Pas was significantly increased by PGD2 in all groups at both doses. We conclude that the pulmonary vasodilator effect of PGD2 in hypoxic neonatal lambs decreases with advancing postnatal age, and that by 14 days, PGD2 is no longer an effective pulmonary vasodilator.
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Welch, K., Lyrene, R., Dew, A. et al. AGE-RELATED VASCULAR EFFECTS OF PROSTAGLANDIN D2 (PGD2). Pediatr Res 18 (Suppl 4), 163 (1984). https://doi.org/10.1203/00006450-198404001-00418
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DOI: https://doi.org/10.1203/00006450-198404001-00418