Abstract
Responses of cerebral arteries to certain vasoactive agents are known to be different from those of extracerebral arteries. We compared vasoconstrictor response to norepinephrine (NE) and vasodilator response to isoproterenol (ISO) between strips of baboon cerebral (CAs) and mesenteric (MAs) arteries and among premature (0.75 gestation), full term newborn and adult baboons for each artery.
The findings indicate (a) Although CAs of PM & NB are much more sensitive to vasoconst. actions of NE than AD, there is no age-related difference in MAs, (b) CAs from PM & NB are more sensitive to vasoconst. actions of NE than MAs, while there is no regional differences in AD, (c) Vasodilation of CAs to ISO is much smaller in AD, whereas that of MAs is slightly greater in AD than in PM & NB, and (d) There is no regional difference in vasodilation to ISO in PM & NB, while vasodilation is much smaller in CAs than MAs in AD. The results show not only maturation-related differences but also regional differences in response to α and β adrenergic agonists.
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Park, M., Hayashi, S., Reif, R. et al. MATURATION-RELATED DIFFERENCES IN ADRENERGIC RESPONSES OF CEREBRAL AND MESENTERIC ARTERIES FROM PREMATURE, NEWBORN AND ADULT BABOONS. Pediatr Res 18 (Suppl 4), 158 (1984). https://doi.org/10.1203/00006450-198404001-00388
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DOI: https://doi.org/10.1203/00006450-198404001-00388