Abstract
Furosemide (F) may have a reduced volume of distribution and prolonged plasma clearance following frequent repeated doses of F in newborn infants. To test whether repeated doses result in plasma accumulation of the drug, four neonates (x̄ bt wgt 1140 g, range: 810-1645), (x̄ gestational age 27 5/7 wks, range: 26-30 wks) with normal renal function were given F, 1 mg/kg/dose IV bolus every 12 hours for 4 doses and maintained normally hydrated during the study period. Serum F levels in mg/l (see table) were measured by HPIC 1 hr after each bolus.
Serum F concentration increased with repeated doses beyond that expected for the reported plasma t½ of 7-19 hrs. Serum F concentration after the second dose was significantly higher than F level after the initial dose (p<0.01). This accumulation of F in the serum of the neonate with repeated doses may reflect delayed plasma clearance and contraction of the volume of distribution superimposed on a prolonged elimination rate. Caution should be observed when given frequent repeated doses of F to newborn infants.
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Chemtob, S., Papageorgiou, A., du Souich, P. et al. ACCUMULATION OF FUROSEMIDE FOLLOWING FREQUENT REPEATED DOSES IN NEWBORN INFANTS. Pediatr Res 18 (Suppl 4), 151 (1984). https://doi.org/10.1203/00006450-198404001-00347
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DOI: https://doi.org/10.1203/00006450-198404001-00347