Abstract
In order to determine the site of production of these steroids and a possible change in responsiveness of the testis and adrenal glands to ACTH and hCG during the 1st year of life, T, DHEA,A, 17 OHP were measured at 1,4,7,9,12 months 1) after a single hCG IM injection (35UI/kg) at 0,6,12,24,30,36 hours in 11 male dogs 2) after a SynacthenR IV bolus (12,5μg/kg at 0,30,60,90 min. in 5 intact and 9,2 weeks old,castrated dogs. First significant T, DHEA, A responses to hCG were observed by the 4th month and mean maximum values increase as the animals get older. These higher levels were reached at 12 hours for DHEA and 24 hours for T and A. The mean levels were almost back to pretest levels in 48 hours. By contrast no elevation of 17 OHP could be seen at all. No elevation of T, A and DHEA could be seen after SynacthenR bolus in all intact and castrated dogs at all ages.
As for 17 OHP the basal level is 0,2 ng/ml approximatively and increased up to 0,6-0,8 ng/ml in all animals except the younger castrated animals (1 and 4 months old) in which the mean peak values were included between 1.1 and 1.5 ng/ml. These data showed a distinct pattern for Leydig cell to hCG, this response occurs here 3 months before onset of puberty. There seems to be no "human" adrenarche in male dog.
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Toublanc, J., Mialot, J., Thibier, M. et al. Testosterone (T), Dehydroepiandrosterone (DHEA), Androstenedione (A) and 17 OHProgesterone (17 OHP) after hCG and ACTH in male dog before and through puberty. Pediatr Res 18, 1230 (1984). https://doi.org/10.1203/00006450-198411000-00177
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DOI: https://doi.org/10.1203/00006450-198411000-00177