Abstract
In search for an optimal induction of puberty, LRH was administered iv in three different consecutive schedules, each lasting for 4 weeks in three hypogonadotropic boys:
Results: Schedule 1 elicited a clear increase of the FSH level, while LH and T (Testosterone) increased slightly.
On the presumed physiologic schedule 2 (Santen and Bardin, 1973) LH, FSH and T increased into the normal adult range.Only 1 patient showed LH pulses strictly coincident with the exogenous LRH pulses. On schedule 3 gonadotropin and T levels remained high or even further increased. There was no evidence of desensitization of the gonadotrophic cells.
These data suggest that:
1. The increase of gonadotropins during early puberty (FSH first, followed by LH) may be the result of increasing LRH stimulation with a pulse frequency lower than presumed physiologic in adults. 2. Pulsatile LRH treatment with a frequency higher than "physiologic" does not result necessarily in desensitization of the gonadotrophic cells, in contrast to observations in the female rhesus monkey (Wildt et al., 1981).
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Delemarre-Van De Waal, H., Schoemaker, J. LRH administration in increasing frequency schedules in the hypogonadotropic male patient. Pediatr Res 18, 1229 (1984). https://doi.org/10.1203/00006450-198411000-00169
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DOI: https://doi.org/10.1203/00006450-198411000-00169