Abstract
The dopaminergic tuberoinfundibular system has been shown to play a role in the regulation of the pituitary secretion of LH an Pr in experimental animals. In humans,DA and DA agonists have an inhibitory effect on LH and Pr release which differs in the two sexes and in women in the different phases of the menstrual cycle. We examined the effect of L-DOPA in the dose used for GH stimulation on the LH,FSH and Pr levels in 9 subjects with Turner syndrome, who had never received estrogens. We found the following (mean ± SD).
Although there is an intense suppressive effect of L-DOPA on plasma Pr concentration there is no synchronous significant decrease in LH. Thus synchronism in Pr and LH suppression caused by adrenergic stimuli in other experimental settings was not detected in the present one. This finding may indicate that there exists a differential, dose related, sensitivity of LH and Pr to the adrenergic stimulus. It may however indicate that the synchronous suppression of LH and Pr by adrenergic stimulus represents age or estrogen-related maturational event.
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Dacou-Voutetakis, C., Christidi, M., Sbokou, D. et al. The effect of L-DOPA on basal LH, FSH and Prolactin (Pr) secretion in subjects with Turner syndrome. Pediatr Res 18, 1227 (1984). https://doi.org/10.1203/00006450-198411000-00158
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DOI: https://doi.org/10.1203/00006450-198411000-00158