Abstract
Pathogenesis of osteoporosis in beta-thalassemia is still nuclear. In 13 thalassemic children: (7,aged 3 to 5 yrs, group 1) and (6aged 10 to 13 yrs, group 2), who had never had vitamin D therapy, we determined serum Ca, P, PTH, CT, 25 OHD3 and 1,25 (OH)2D3 levels both in winter and in summer, in comparison with 2 groups of 14 controls of the same age. The results were similar in thalassemic and in controls. In thalassemic patients of group 2, serum PTH (0.61±0.43 ng/ml), 25 OHD3 (23,9±11.2. ng/ml), 1.25 (OH)2D3 (14.9±6.7 pg/ml) levels were lower than in controls (PTH: 1.52±0.47ng/ml;25 OHD3: 32.7±12.4 ng/ml 1,25 (OH)2D3: 36.1±13.7 pg/ml), whereas serum CT levels (305±79pg/ml were higher than in controls (107±35pg/ml). No significant differences exist between winter and summer; only 25 OHD3levels were higher in summer than in winter in thalassemic patients and in controls. Conclusions: advancing age induces in thalassemic patients a decrease in PTH secretion and consequently a deficit in synthesis of 1.25 (OH) 2 D3. This may explain some aspects of osteoporosis, which CT hyper-secretion may tend to counter to.
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Zamboni, G., Marradt, P., Tagliaro, F. et al. Parathyroid hormone, calcitonin and 1, 25 (OH)2D3. levels in betathalassemia major. Pediatr Res 18, 1224 (1984). https://doi.org/10.1203/00006450-198411000-00140
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DOI: https://doi.org/10.1203/00006450-198411000-00140