Abstract
High values of immunoreactive CT (iCT) found in newborns are yet inexplicated. The results of the iCT assays are impaired by the immunoheterogeneity of the hormone causing a discordance of the results obtained with different antisera. A purification by hydrophobic interaction chromatography may yield a high accuracy of the determation of the hormone. iCT, pCT and T3, T4, TSH were assayed in the cord and at 3.12.24.48 hours from delivery in 15 newborns, hospitalized for nonendocrine diseases. 1 ml blood/point was drawn only if venipuncture was otherwise clinically indicated. iCT values (cord 135 ± 33.6 pg/ml) significantly increased ( p <0.01) at 12h (402 ± 53) and persisted high at 24h (611 ± 66) and at 48h (371 ± 43). pCT significantly increased (p < 0.01) at 3h (from 17.3 ± 4.0 to 28.5 ± 6.0) with a peak at 12h (100 ± 28.2) and decreased at 24h (72 ± 28.2) and at 48h (33 ± 2.8). In conclusion: a peak of CT in the neonate seems to be related to the stress typical for delivery.
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Tato, L., Dorizzi, R., Avanzini, S. et al. Calcitonin (pCT) in the first hours of life. Pediatr Res 18, 1224 (1984). https://doi.org/10.1203/00006450-198411000-00138
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DOI: https://doi.org/10.1203/00006450-198411000-00138