Abstract
Twentyfour patients with GD, aged 4 to 18 years, were studied before, during and after antithyroid treatment. FT4-level was determined by Amersham RIA-kit (110 samples), TRH-test was carried out with RELEFACT (Hoechst) using Byk Mallinckrodt TSH RIA kit (56) and TSH receptor binding was detected by the assay of Shewring and Rees Smith (53). The diagnostic values of FT4-RIA and TRH-test were excellent in this material. The TSH receptor antibody results were positive (greater than 15%) in one or more samples of 15 patients out of 24, showing the nature of the disease. The prognostic value of the FT4-RIA is valuable only in short time prognosis: sometimes the relapse was indicated first by increase of the FT4-level. The bad prognosis of GD was predicted better by the TRH-test but good prognosis by the TSH receptor binding assay. The value of TRH-test and TSH receptor binding assay has been poor for choosing the adequate stopping time of antithyroid treatment in 50 % of cases.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peter, F., Smith, B. & Blatniczkv, L. Comparative study on diagnostic and prognostic value of FT4-level, TRH-test and TSH receptor binding assay in Graves disease (GD). Pediatr Res 18, 1223 (1984). https://doi.org/10.1203/00006450-198411000-00134
Issue Date:
DOI: https://doi.org/10.1203/00006450-198411000-00134