Abstract
The pathogenesis of diabetic vascular disease is not clear.Alterations in hemostasis and in hemorheology may play an important role in pathogenesis and/or propagation of diabetic vascular disease. To investigate, whether alterations in blood rheology can be shown prior to the first detectable signs of vascular disease, viscosity of blood, plasma, and red blood cell (RBC) suspensions, filterability of RBC suspensions, fibrinogen,alpha2-macroglobulin, and plasma fibronectin (PFN) were studied in 25 diabetic children. All were without signs of diabetic vascular disease. Viscosity of blood and of RBC suspensions in plasma were significantly higher, filterability of RBC suspensions in plasma was significantly lower in the group with poor diabetic control.Plasma viscosity, fibrinogen and alpha2-macroglobulin levels did not differ in the groups, but PFN was significantly elevated in the group with poor control. Our results show that rheological alterations can be demonstrated in diabetic children without vascular disease but with poor diabetic control. These alterations seem mainly due to an elevated tendency of the RBC to aggregate in their native plasma. Elevated PFN might be the cause for the observed rheological alterations.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Borkenstein, M., Muntean, W. & Ott, E. Elevated plasma fibronectin is associated with increased blood viscosity and red cell aggregation in diabetic children. Pediatr Res 18, 1219 (1984). https://doi.org/10.1203/00006450-198411000-00108
Issue Date:
DOI: https://doi.org/10.1203/00006450-198411000-00108
This article is cited by
-
Intranasal LH-RH for cryptorchidism: response to initial treatment and to treatment after relapse
European Journal of Pediatrics (1987)