Abstract
The role of LHRH nasal spray was assessed in 40 boys with 54 undescended testes (UDT). Subjects were divided randomly into three groups: eighteen placebo, twelve low dose (600 micrograms daily) and ten full dose (1200 micrograms), who had 25, 16 and 13 UDT's respectively. They were assessed independently by two observers before and after treatment, which lasted four weeks. No clinical improvement was seen in any of the placebo group who all required surgery. Improvement was seen in 5/16 testes of the low dose group and 7/13 in the high dose group and these did not require operation.
Improvement was only in those testes which initially could be manipulated to below the external inguinal ring. LHRH spray may have some benefit in these cases and help define which need orchidopexy.
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Swift, P., Klidjian, A. & Johnstone, J. A DOUBLE BLIND, CONTROLLED STUDY OF LUTEINISING-HORMONE RELEASING HORMONE (LHRH) IN THE MANAGEMENT OF UNDESCENDED TESTIS. Pediatr Res 18, 1218 (1984). https://doi.org/10.1203/00006450-198411000-00103
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DOI: https://doi.org/10.1203/00006450-198411000-00103
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