Abstract
The effect of oxandrolone (Ox) on the spontaneous hGH-secretion was studied in 6 prepubertal children diagnosed as constitutional delay of growth and adolescence (CD). The spontaneous secretion pattern of hGH during a 24hrs. period was analysed before and after a 5-8 weeks therapy with Ox, 1.0 mg/kg daily. Blood samples were taken in 60 min. intervalls. All patients had well documented sleeping phases during night. For evaluation we looked for the integrated hGH-concentrations (ng × min × ml-1;(1)) as a parameter for the total secretion per day, the 3 maximal peak values and the number of secretion periods. Results: Comparing the hGH-secretion pattern before and after Ox (Wilcoxon-test, 95% confidence level), no differences were proven regarding the criteria mentioned.Conclusion: Ox does not stimulate the spontaneous hGH-secretion in patients with CD and may exert its growth promoting activity in another way.
(1) BIERICH, J.R. (1983) Klin. Pädiat. 195:309
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Stolecke, H., Gillessen, G. Oxandrolone and spontaneous hGH-secretion. Pediatr Res 18, 1216 (1984). https://doi.org/10.1203/00006450-198411000-00093
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DOI: https://doi.org/10.1203/00006450-198411000-00093