Abstract
To investigate GH dynamics in tall girls an integrated 24hGH-analysis has been performed in 12 tall pubertal girls collecting a sample every 20 min using a Kowarski-Cormed pump.The effect of Oe 500 ug daily (5pat) or B 5-7,5 mg(7pat) on spontaneous GH secretion has been studied by repeating the 24h analysis. On Oe treatment every girl increased the area under the curve, mean peak amplitude and the GH-level between peaks, so but less pronounced, did 4 out of 5 patients on B. On Oe the number of peaks was unchanged, on B slightly reduced. Somatomedin A (K.Hall) decreased during Oe-therapy, data yet not available on B. Growth-rate was reduced during Oe, unchanged on B treatment. The growth inhibiting effect of Oe is not mediated by GH but by SM and by acceleration of bone age. Growth inhibition of B if any, is unexplained.
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Westphal, O., Wikland, K. Secretory pattern of growth hormone (GH) in tall girls treated with Ethinyloestradiol (Oe)or Bromocriptine(B). Pediatr Res 18, 1213 (1984). https://doi.org/10.1203/00006450-198411000-00073
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DOI: https://doi.org/10.1203/00006450-198411000-00073