Abstract
To investigate the possible role of autoimmune phenomenons during the remission period in type I diabetes, we have studied the time-course of two immunological markers in 7 diabetic children (age:1.5-7 y). During 12 months following diagnosis, we determined: 1)cytotoxic islet cells antibodies(CICA) by the release of 51CR from mice islet cells after complement fixation;2) inhibitory lymphocytes(IL)tested by the inhibition of mice islet cells insulin secretion after patients lymphocytes addition. All the children have been treated by highly purified pork insulin. 5/7 children underwent a remission period (insulin requirements<0.5 U/kg/d) within the first weeks of treatment. CICA were found positive in 85% of the children at the time of diagnosis, and were decreasing after 6 months of disease(10% of positive sera at 12 months).CICA titration was not stable in a same patient. IL were found in 85% of the children at the onset and remained elevated,(80% at 12 months)despite a slight decrease after 6 months of disease. No correlation was found between insulin requirements and immunological parameters. In conclusion :-CICA were present in diabetic children with a high frequency early after diagnosis, which was decreasing after 6 months. -IL were present as well early after diagnosis. They appeared to be more stable during the first year of disease.
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Levy-Marchm, C., Quiniou, M., Debray-Sachs, M. et al. Longitudinal study of cytotoxic antibodies and inhibitory lymphocytes in 7 diabetic children during the first year of their disease. Pediatr Res 18, 1212 (1984). https://doi.org/10.1203/00006450-198411000-00069
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DOI: https://doi.org/10.1203/00006450-198411000-00069