Abstract
In an attempt to elucidate the pathophysiology of the hypocalcemia which occurs in fulminant meningococcaemia we found inapropriate immunoreactive hypercalcitoninemia (iCT) (Lancet 1983 ; 1 : 294). It appeared nescessary to determined if CT detected corresponds to CT 1-32 and what causes this hyper CT. Some pathologic situations were investigated. iCT was determined by radioimmunoassay (Mallinckrodt).
Therefore to appreciate the iCT detected, radioimmunoassay curves were performed. Results with infants sera dilutions were not similar to those obtained with human synthetic CT used as standard or medullary carcinoma sera. These data lead to speculate : that iCT detected probably is not CT 1-32. This hyper CT "like" is correlated with shock syndrom especially from septic origin and despite the correlation with hypocalcemia is probably only one of shock syndrom biological signs.
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Mallet, E., Meurant, A., Devauxa, A. et al. IMMINOREACTIVE HYPERCARLCITONINEMIA IN FULMINANT MENINGOCOCCARMIA IN CHILDREN. Pediatr Res 18, 811 (1984). https://doi.org/10.1203/00006450-198408000-00106
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DOI: https://doi.org/10.1203/00006450-198408000-00106