Abstract
Zinc is required for the synthesis of Vitamin A (Vit.A) carrier proteins - retinol binding protein (RBP) and prealbumin (PA). Low plasma zinc and Vit.A have been observed in CF. We have studied the relationship between plasma levels of Vit.A, RBP and PA with plasma zinc in 37 patients with CF and 25 similar aged controls. There was no statistically significant difference between CF patients and controls for plasma Vit.A and zinc concentrations. In CF patients there was a significant correlation between Vit.A and RBP (r = 0.69, p <0.001) and PA (r = +0.80, p <0.001). In control subjects there was a significant correlation between Vit.A and RBP (r = 0.56, p < 0.01) but not with PA (r = +0.17, NS). In CF patients RBP and PA were correlated with the following
Thus we were unable to find evidence of low plasma Vit.A or plasma zinc concentrations in a fairly healthy (median Shwachmann score 82) group of patients with CF. There was no correlation between plasma zinc and Vit.A carrier proteins.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mughal, M., Wells, F. & Hameleton, G. PLASMA VITAMIN A AND ZINC ON CYSTIC FIBROSTS (CF). Pediatr Res 18, 805 (1984). https://doi.org/10.1203/00006450-198408000-00082
Issue Date:
DOI: https://doi.org/10.1203/00006450-198408000-00082