Abstract
Total parenteral nutrition (TPN) is important in the management of ill newborns. The difference in metabolic rate (MR) and substrate use (SU) between infants receiving TPN with and without fat emulsion have not been fully defined. We compared MR and SU by indirect calorimetry (IC) in infants receiving a glucose/amino acid mixture only (2% Vamin/DIOW), group I, with infants (group II) receiving a fat emulsion (Nutralipid 10%) as well. Birthweight, gest. age, postnatal age and weight were similar. IC was performed for 4±1 h. MR and SU are calculated from the protein-free RQ and VO2.
CONCLUSIONS: 1) MR is significantly higher in infants receiving glucose-amino acids alone. 2) VCO2 is higher in group I. 3) This might be caused by a higher conversion of glucose to fat in group I which is energy consuming. 4) We found no effect on protein balance. 5) TPN with lipids has advantages over TPN without lipids.
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Sauer, P., Van Aerde, J., Smith, J. et al. SUBSTRATE UTILISATION OF NEWBORN INFANTS FED INTRAVENOUSLY WITH OR WITHOUT A FAT EMULSION. Pediatr Res 18, 804 (1984). https://doi.org/10.1203/00006450-198408000-00074
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DOI: https://doi.org/10.1203/00006450-198408000-00074