Abstract
Massive overweight is related to an increased risk for coronary heart disease, while lipids and lipoproteins are frequently normal or only slightly altered. To elucidate possible changes of apoproteins in obese adolescents 40 grossly obese adolescents,46 ± 13% overweight aged 11.5 ± 1.0 yrs. and 26 normalweight subjects aged 11.8±0.8 yrs. were investigated. Serum cholesterol (C) and triglycerides (TG) were determined enzymatically, lipoproteins by ultracentrifugation and apoproteins by electroimmunoassay.
While for lipids and LP no differences could be shown, apoprotein levels differ markedly in the obese group: The lower concentrations of Apo AI and the higher levels of Apo B indicate an altered lipoprotein composition, which might be associated with an increased incidence of coronary heart disease.
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Zwiauer, K., Widhalm, K. & Strobl, W. LIPIDS, LIPOPROTEINS AND APOPROTEINS IN GROSSLY OBESE ADOLESCENTS. Pediatr Res 18, 803 (1984). https://doi.org/10.1203/00006450-198408000-00072
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DOI: https://doi.org/10.1203/00006450-198408000-00072