Abstract
Dept.of Paed.,The National Hospital of Norway, Oslo,Childrens Hospital,Helsinki and Research Institute for lung diseases, Berlin-Buch,GDR. During post hypoxic resuscitation the hypoxanthine-xanthine oxidase system creates free oxygen radicals. The effect of free oxygen radicals on the lungs were studied by applying 1 U XO into the trachea of guinea pigs. Lung compliance and arterial blood gases were monitored. Compliance and PaO2 decreased (p<0.01) after application of XO in 1 ml saline (3 ml/kg), when compared with saline alone. SOD (20000 U) prevented the effect of XO. When ventilating with a peak pressure of 20 cm H2O 20 minutes after application of the fluid the data were:
The data demonstrate that XO potently damages the lungs probably through O2- formation since SOD prevents the effect. The SOD effect lasts about one hour. The data also show that there is a dramatic effect on healthy lungs when saline is applied into the trachea. This raises the question whether randomised studies for surfactant treatment are justified.
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Saugstad, O., Hallman, M., Becher, G. et al. Protective effect of superoxid dismutase (SOD) on severe lung damage caused by xanthine oxidase (XO). Pediatr Res 18, 802 (1984). https://doi.org/10.1203/00006450-198408000-00063
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DOI: https://doi.org/10.1203/00006450-198408000-00063
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